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. 2014 Mar 13;2:599–609. doi: 10.1016/j.redox.2014.03.003

Fig. 7.

Fig. 7

Schematic representation of the putative mechanisms involved in EFV/INH-mediated hepatic mitochondrial dysfunction and its prevention by MB. (A) Inhibition by EFV of complex I and hydrazine-mediated inhibition of complex II in combination results in peroxynitrite stress, opening of the mPT, and eventually oncotic necrosis. (B) MB acts as an electron acceptor from NADH at complex I, and MBH2 directly reduces cytochrome c, bypassing the upstream components of the ETC, thus protecting hepatocytes against EFV/INH-induced lethal cell injury.