Video 1. Behavioral defects of Nf1^hGFAPCKO mice before and after MEKi treatment.

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DOI: 10.7554/eLife.05151.003

This video illustrates the typical phenotypes seen in vehicle-treated and untreated Nf1^hGFAPCKO mice compared to controls including scruffy fur, unbalanced gait, vertical projection of the tail, hyperactivity, hind-limb crossing, and hand-standing. Following MEKi treatment, the G-responders appear similar to the controls except the vertical projection of the tail, while the P-responders are more similar to the vehicle-treated mutants. All the mice in this video are P21 except the mouse with the hand-standing phenotype, which was videotaped at 4 months of age.

DOI: http://dx.doi.org/10.7554/eLife.05151.003