Table 1.

Human genes known to harbor NCL-causing mutations and their orthologs known to cause NCL in dogs

Human disease	Mutant gene	Mutant protein	Canine disease described?
CLN1	PPT1 [2]	Palmitoyl-protein thioesterase 1	Yes [16]
CLN2	TPP1 [3]	Tripeptidyl peptidase 1	Yes [17]
CLN3	CLN3 [4]	CLN3	No
CLN4	DNAJC5 [5]	DNAJC5	No
CLN5	CLN5 [6]	CLN5	Yes [18]
CLN6	CLN6 [7,8]	CLN6	Yes [19]
CLN7	MFSD8 [9]	MFSD8	Yes [Current report]
CLN8	CLN8 [10]	CLN8	Yes [20,21]
CLN10	CTSD [11]	Cathepsin D	Yes [22]
CLN11	GRN [12]	Granulin	No
CLN12	ATP13A2 [13]	ATP13A2	Yes [23,24]
CLN13	CTSF [14]	Cathepsin F	No
CLN14	KCTD7 [15]	KCTD7	No