Skip to main content
. 2015 Jan 13;23(1):1. doi: 10.1186/s40199-015-0089-6

Table 5.

Effect of the administration of fucoïdanes isolated from C. sedoides, C. compressa and C. crinita and reference drugs in carrageenan induced rat paw edema

Samples Dose (mg/kg) Edema (mL × 10 −2 ) Edema inhibition (%)*
1 h 3 h 5 h 1 h 3 h 5 h
Control - 26 ± 2.75 57.5 ± 1.51 59 ± 3.27 - - -
ASL (reference) 300 17.66 ± 1.63 24.83 ± 1.72 29.33 ± 1.21 32.07 56.81 50.28
Diclofenac (reference) 10 15.66 ± 5.12 25.83 ± 2.40 28.66 ± 3.61 39.76 55.07 51.42
Fucoidans C. sedoides 25 13.66 ± 3.20*** 29.66 ± 5.20*** 40.16 ± 4.70*** 47.46a 48.41a 31.93a
50 10.66 ± 4.08*** 28.16 ± 3.38*** 41.66 ± 1.21*** 59.00b 51.02a 29.38a
C. compressa 25 12.66 ± 2.73*** 26.83 ± 1.04*** 29.83 ± 2.40*** 51.30a 53.33a 49.44a
50 11.83 ± 4.09*** 24.83 ± 2.48*** 28.00 ± 2.36*** 54.50a 56.81a 52.54a
C. crinita 25 12.66 ± 3.43*** 26.50 ± 3.39*** 19.83 ± 1.94*** 51.28a 54.17a 66.38a
50 13.20 ± 2.68*** 24.16 ± 2.56*** 28.50 ± 2.50*** 49.23a 58.21a 51.69b

Data are expressed as mean ± s.e.m. (n = 6).

*Mean values with different superscript letters in the same row are significantly different at p ≤ 0.05.

***p < 0.001.