Table 6.
Results of antiulcerogenic activity of fucoïdanes isolated from C. sedoides, C. compressa and C. crinita on gastric ulcer induced by HCl/ethanol solution
| Samples | Dose (mg/kg) | Average lesion (mm) | Ulcer inhibition (%)* | |
|---|---|---|---|---|
| Control | _ | 50.33 ± 5.50 | _ | |
| Ranitidine (reference) | 60 | 43.38 ± 4.35 | 66.96 | |
| Oméprazole (reference) | 30 | 17.50 ± 1.38 | 86.67 | |
| Fucoidans | 25 | 20.83 ± 2.56*** | 58.57 ± 5.09a | |
| 50 | 16.00 ± 2.19*** | 68.19 ± 4.35b | ||
| C. sedoides | 25 | 22.83 ± 3.70*** | 54.60 ± 7.37a | |
| 50 | 15.83 ± 4.60*** | 68.51 ± 5.24b | ||
| C. crinita | 25 | 28.33 ± 4.09*** | 43.66 ± 5.13a | |
| 50 | 20.17 ± 6.17*** | 59.90 ± 7.26b | ||
Data are expressed as mean ± s.e.m. (n = 6).
*Mean values with different superscript letters in the same row are significantly different at p ≤ 0.05.
***p < 0.001.