Table 1.
Main characteristics of the 368 study patients divided according to the therapeutic choice
| Group AVR 141 pts | Group TAVI 127 pts | Group BAV 49 pts | Group MT 51 pts | |
|---|---|---|---|---|
| • Age (years) | 72 ± 10 | 83 ± 8* | 84 ± 9* | 81 ± 7* |
| • Female gender (%) | 52 | 32 | 49§ | 29*# |
| • Hypertension (%) | 77 | 75 | 69 | 73 |
| • Diabetes (%) | 27 | 25 | 20 | 25 |
| • Atrial fibrillation (%) | 27 | 39 | 28 | 37 |
| • NYHA function class (1–4 scale) | 2.3 ± 0.8 | 2.6 ± 0.6* | 2.9 ± 0.8*§ | 2.9 ± 0.8*§ |
| • History of heart failure (%) | 60 | 73* | 88*§ | 76* |
| • Chronic obstructive pulmonary disease (%) | 16 | 22 | 39*§ | 25 |
| • Left bundle branch block (%) | 8 | 17* | 20* | 16* |
| • Kidney disease (%) | 32 | 65* | 71* | 71* |
| • Glomerular filtration rate (ml/min/1.73) | 73 ± 26 | 54 ± 23* | 47 ± 26*§ | 48 ± 28*§ |
| • Haemoglobin (g/dl) | 11.7 ± 1.8 | 11.9 ± 1.5 | 11.8 ± 1.4 | 11.9 ± 1.6 |
| • Serum total colesterol (mg/dl) | 162 ± 45 | 184 ± 47* | 162 ± 29§ | 159 ± 38* |
| • Charlson comorbidity index | 2.1 ± 1.5 | 3.5 ± 1.7* | 3.5 ± 1.7* | 3.7 ± 2.0* |
| • Katz score | 2.8 ± 1.7 | 3.8 ± 1.9* | 3.8 ± 1.9* | 4.2 ± 2.2* |
| • EUROSCORE | 16 ± 12 | 28 ± 18* | 33 ± 18* | 31 ± 20* |
| • LV relative wall thickness | 0.55 ± 0.11 | 0.55 ± 0.11 | 0.55 ± 0.14 | 0.56 ± 0.13 |
| • LV mass (gr/m2) | 209 ± 56 | 217 ± 59 | 541 ± 72*§° | 207 ± 71# |
| • LV end-diastolic diameter (mm) | 50.7 ± 0.8 | 50.7 ± 0.8 | 52.3 ± 0.9 | 50. ± 0.9 |
| • LV end-diastolic volume (ml) | 139 ± 69 | 141 ± 69 | 155 ± 79 | 132 ± 67 |
| • LV ejection fraction (%) | 53 ± 11 | 51 ± 12 | 41 ± 11*§° | 50 ± 10# |
| • Pulmonary artery systolic pressure (mmHg) | 38 ± 11 | 43 ± 14* | 47 ± 15*§° | 43 ± 12* |
| • Aortic valve area (cm2/m2) | 0.41 ± 0.10 | 0.35 ± 0.08*° | 0.34 ± 0.12*° | 0.42 ± 0.13§# |
| • Trans valve area peak gradient (mmHg) | 79 ± 24 | 86 ± 22* | 71 ± 27§ | 76 ± 24§ |
| • Biscuspid aortic valve (%) | 8 | 1* | 4 | 6 |
| • Beta-blockers (%) | 42 | 28* | 21* | 35 |
| • ACE-inhibitors/ARBs (%) | 65 | 67 | 37*§° | 65# |
| • Diuretics (%) | 70 | 83* | 95* | 75 |
| • Statins (%) | 46 | 53 | 45 | 63 |
| • Warfarin (%) | 80 | 60* | 55* | 45* |
ACE = angiotensin-converting enzyme; ARB = angiotensine receptor blockers; AVR = traditional surgical aortic valve replacement; BAV-baloon aortic valvuloplasty; LV = left ventricular; MT = Medical Therapy; HYHA = New York Heart Associations; TAVI = tanscatheter aortic valve implentaions..
p & 0.05 vs AVR = *; vs TAVI = §; vs BAV = #; vs MT = °.