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. 2014 Dec 3;16(6):484. doi: 10.1186/s13075-014-0484-2

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© Wen et al.; licensee BioMed Central. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Interleukin 1β (IL-1β) modulated glycosaminoglycan (GAG) synthesis and UDP-glucose dehydrogenase ( UGDH ) gene expression. Human articular chondrocytes were treated with recombinant IL-1β for 12 h, 24 h and 48 h. Then, GAG content (A) and the mRNA level of UGDH (B) of chondrocyte cultures was detected. Meanwhile, UGDH protein level from chondrocytes treated with IL-1β for 48 h was detected using western blotting assay (C, D). Values were presented as mean ± standard error of the mean from at least three independent experiments. *P <0.05 and **P <0.01 versus control.