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. 2014 Nov 18;16(6):478. doi: 10.1186/s13075-014-0478-0

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© Rong et al.; licensee BioMed Central. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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High MPA levels and positive correlations with Mon2 and with the expression of CD147 on platelets and Mon2. (A) The percentages of platelets that aggregated with monocytes and (B) the monocyte subsets in healthy controls (n = 10), patients with inactive RA (n = 10) and patients with active RA (n = 30). MPA levels (C) vs. the percentage of Mon2 (r = 0.66, P <0.0001), (D) vs. the expression of CD147 on platelets (r = 0.61, P = 0.0004) and (E) vs. the expression of CD147 on Mon2 monocytes (r = 0.77, P <0.0001) within the group of patients with active RA (means ± SDs of the mean, ^* P <0.05, ^** P <0.001 and ^*** P <0.0001 vs. corresponding controls). HD: healthy donors; P: platelet; MPA: monocyte-platelet aggregates; Mon1: CD14⁺⁺CD16⁻CCR2⁺; Mon2: CD14⁺⁺CD16⁺CCR2⁺; Mon3: CD14⁺CD16⁺⁺CCR2⁻; RA: rheumatoid arthritis.