Table 2.
Top associations between SNPs and HbA2 in CSSCD GWAS.
| Adjusted for age and sex | Adjusted for age, sex, and HbF | Mediation by HbF | |||||||
|---|---|---|---|---|---|---|---|---|---|
| CHR | SNP | BP | MAF | A1 | Effect | P | Effect | P | P |
| 2 | rs766432 | 60573474 | 0.29 | C | −0.195 | 8.10E-08 | −0.1326 | 4.98E-04 | 3.50E-05 |
| 2 | rs10195871 | 60574093 | 0.33 | A | −0.166 | 1.69E-06 | −0.112 | 1.64E-03 | 2.35E-05 |
| 2 | rs17020489 | 81675692 | 0.3 | A | 0.1787 | 8.00E-07 | 0.1668 | 2.20E-06 | 1.73E-01 |
| 2 | rs17020632 | 81765823 | 0.31 | C | 0.1667 | 4.17E-06 | 0.161 | 4.75E-06 | 5.13E-01 |
| 2 | rs1113932 | 192760598 | 0.06 | G | 0.2881 | 2.00E-05 | 0.2895 | 9.95E-06 | 9.31E-01 |
| 8 | rs822278 | 16536220 | 0.47 | G | 0.1613 | 8.89E-07 | 0.1539 | 1.40E-06 | 3.49E-01 |
| 8 | rs1425912 | 54241746 | 0.36 | G | 0.1572 | 7.65E-06 | 0.1532 | 7.09E-06 | 6.37E-01 |
| 10 | rs10887055 | 123789677 | 0.26 | G | 0.1746 | 2.51E-06 | 0.1523 | 2.70E-05 | 1.55E-02 |
| 11 | rs11021763 | 11273929 | 0.37 | G | 0.1474 | 2.39E-05 | 0.1502 | 9.09E-06 | 7.45E-01 |
| 13 | rs1536807 | 40267790 | 0.44 | A | −0.1514 | 8.11E-06 | −0.1371 | 3.39E-05 | 8.19E-02 |
| 13 | rs2940695 | 107365156 | 0.25 | A | 0.175 | 5.24E-06 | 0.1665 | 8.19E-06 | 3.61E-01 |
| 14 | rs2296274 | 60986931 | 0.15 | A | −0.2204 | 3.49E-06 | −0.2063 | 8.00E-06 | 2.19E-01 |
| 16 | rs11150150 | 77897032 | 0.34 | G | −0.1627 | 4.21E-06 | −0.1501 | 1.31E-05 | 1.39E-01 |
| 20 | rs6038123 | 5220152 | 0.2 | A | −0.2138 | 4.69E-06 | −0.2193 | 1.37E-06 | 6.19E-01 |
SNPs significant at p<1E-05 in at least one analysis of CSSCD.