Table 1. List of 165 fly genes and 259 corresponding human homologs identified from the screen.
Human genes associated with Mendelian disease are marked with an asterisk and bold type, the corresponding fly gene is shown in bold. See also Table S1, S5.
| Fly Gene | Human Homologs (*OMIM) |
|---|---|
| Aats-his | HARS*, HARS2* |
| AP-1γ | AP1G1, AP1G2, AP4E1* |
| ari-1 | ARIH1 |
| arm | CTNNB1* |
| Arp2 | ACTR2 |
| ATP7 | ATP7A*, ATP7B* |
| baz | PARD3, PARD3B |
| ben | UBE2N |
| br | - |
| Brms1 | BRMS1, BRMS1L |
| cac | CACNA1A*, CACNA1B CACNA1E |
| Cap | SMC3* |
| car | VPS33A |
| CDC45L | CDC45L |
| Cdk7 | CDK7 |
| CG11409 | - |
| CG11417 | ESF1 |
| CG11418 | MTPAP* |
| CG12125 | FAM73A, FAM73B |
| CG12991 | - |
| CG13365 | - |
| CG14442 | ZNF821 |
| CG14786 | LRPPRC* |
| CG15208 | C21orf2 |
| CG15896 | KIAA0391 |
| CG1597 | MOGS* |
| CG1703 | ABCF1 |
| CG1749 | UBA5 |
| CG17776 | - |
| CG17829 | HINFP |
| CG18624 | NDUFB1 |
| CG2025 | NRD1 |
| CG2918 | HYOU1 |
| CG3011 | SHMT1, SHMT2 |
| CG3149 | RFT1* |
| CG32649 | ADCK3*, ADCK4 |
| CG32694 | - |
| CG32795 | TMEM120A, TMEM120B |
| CG34401 | ZSWIM8 |
| CG3446 | NDUFA13* |
| CG3704 | GPN1 |
| CG3857 | SMG9 |
| CG4078 | RTEL1* |
| CG4165 | USP16 |
| CG42237 | PLA2G3, PROCA1 |
| CG42593 | UBR3 |
| CG42749 | - |
| CG4407 | FLAD1 |
| CG4542 | ALG8* |
| CG7065 | - |
| CG7358 | ZC3H13 |
| CG8184 | HUWE1* |
| CG8636 | EIF3G |
| CG8949 | WAC |
| CG9650 | BCL11A, BCL11B, ZNF296 |
| Chc | CLTC, CLTCL1 |
| CkIIbeta | CSNK2B |
| CkIα | CSNK1A1, CSNK1A1L |
| comt | NSF |
| COQ7 | COQ7 |
| Crag | DENND4A, DENND4B, DENND4C |
| Cyp4d2 | CYP4V2* |
| DAAM | DAAM1, DAAM2 |
| dlg1 | DLG1, DLG2, DLG3*, DLG4 |
| Dlic | DYNC1LI1, DYNC1LI2 |
| dor | VPS18 |
| dsh | DVL1, DVL2, DVL3 |
| Dsor1 | MAP2K1*, MAP2K2* |
| dwg | MZF1, ZSCAN22 |
| Efr | SLC35B4 |
| egh | - |
| eIF2B-ε | EIF2B5* |
| elav | ELAVL1, ELAVL2, |
| ELAVL3, ELAVL4 | |
| ewg | NRF1 |
| fh | FXN* |
| fliI | FLII |
| flw | PPP1CB |
| fs(1)h | BRD2, BRD3, BRD4, BRDT |
| Fur2 | PCSK5, PCSK6 |
| Gtp-bp | SRPR |
| hfw | - |
| Hlc | DDX56 |
| hop | JAK1, JAK2*, JAK3*, TYK2* |
| Hr4 | NR6A1 |
| Hsc70-3 | HSPA5 |
| Inx2 | - |
| kdn | CS |
| l(1)1Bi | MYBBP1A |
| l(1)G0156 | IDH3A |
| l(1)G0222 | ANKLE2 |
| l(1)G0230 | ATP5D |
| l(1)G0255 | FH* |
| l(1)G0334 | PDHA1*, PDHA2 |
| Marf | MFN1, MFN2* |
| Mcm6 | MCM6* |
| mew | ITGA3*, ITGA6*, ITGA7* |
| mRNA-cap | RNGTT |
| mRpL38 | MRPL38 |
| mRpS25 | MRPS25 |
| mRpS30 | MRPS30 |
| mst | MSTO1 |
| mus101 | TOPBP1 |
| mxc | NPAT |
| Myb | MYB*, MYBL1, MYBL2 |
| mys | ITGB1, ITGB2*, ITGB4*, ITGB5, ITGB6, ITGB7, ITGB8 |
| N | NOTCH1*, NOTCH2*, |
| NOTCH3*, NOTCH4 | |
| nej | CREBBP*, EP300* |
| Nmd3 | NMD3 |
| nonC | SMG1 |
| Nrg | CHL1, L1CAM*, NFASC, NRCAM |
| Nup93-1 | NUP93 |
| oc | CRX*, OTX1, OTX2* |
| para | SCN1A*, SCN2A*, SCN3A, SCN4A*, SCN5A*, SCN7A, SCN8A*, SCN9A*, SCN10A*, SCN11A* |
| parvin | PARVA, PARVB, PARVG |
| pck | CLDN12 |
| Pgd | PGD* |
| phl | ARAF, BRAF*, RAF1* |
| PI4KIIIalpha | PI4KA |
| por | PORCN* |
| pot | - |
| PpV | PPP6C |
| Prosα4 | PSMA7, PSMA8 |
| Psf3 | GINS3 |
| rap | FZR1 |
| Rbcn-3A | DMXL1, DMXL2 |
| Rbcn-3B | WDR7, WDR72* |
| Rbf | RB1*, RBL1, RBL2 |
| Rhp | RHPN1, RHPN2 |
| RpII215 | POLR2A |
| RpS5a | RPS5 |
| Sas10 | UTP3 |
| schlank | CERS1, CERS2, CERS3*, CERS4, CERS5, CERS6 |
| scu | HSD17B10* |
| Sec16 | SEC16A, SEC16B |
| sgg | GSK3A, GSK3B |
| shi | DNM1, DNM2*, DNM3 |
| sicily | NDUFAF6* |
| skpA | SKP1 |
| Smox | SMAD2, SMAD3* |
| smr | NCOR1, NCOR2 |
| SNF1A | PRKAA1, PRKAA2 |
| sno | SBNO1, SBNO2 |
| Sp1 | SP7*, SP8, SP9 |
| stim | STIM1*, STIM2 |
| svr | CPD |
| tay | AUTS2 |
| temp | PTAR1 |
| TH1 | NELFCD |
| tko | MRPS12 |
| trr | KMT2C, KMT2D* |
| ubqn | UBQLN1, UBQLN2*, UBQLN3, UBQLN4, UBQLNL |
| Upf1 | UPF1 |
| Upf2 | UPF2 |
| Usf | USF1, USF2 |
| Usp7 | USP7 |
| vnd | NKX2-2, NKX2-8 |
| Vps26 | VPS26A, VPS26B |
| wapl | WAPAL |
| wds | WDR5, WDR5B |
| wus | DNAJC22 |
| Ykt6 | YKT6 |
| Zpr1 | ZNF259 |
| βCop | COPB1 |
| β-Spec | SPTB*, SPTBN1, SPTBN2*, SPTBN4 |
| δCOP | ARCN1 |