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Long-range signaling in the frog embryo. Oncogene-expressing cells (red, Xrel3-tdTomato) are prevented from forming tumors by hyperpolarizing channel-expressing cells (Kv 1.5-β-gal) located at a distance. Compare (A) without to (B) with Xrel3-tdTomato. The ~4 mm distance from the center of the tdTomato signal to the farthest point on the tail expressing β-gal was estimated to be ~300 cell diameter (average single cell diameter of 13.3 μm).
