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Biological profiles for analogues 23, 31-32, 37 and 34, selectivity index refers to BSF parasitic inhibition versus mammalian HeLa inhibition.
| |||||
|---|---|---|---|---|---|
| Entry | Analogue | T.brucei(BSF) EC50(μM) | T.brucei(Pro) EC50(μM) | Hela EC50(μM) | Selectivity Index |
| 1 | 23 | 1.8 ± 0.1 | 0.8±0.1 | 7.0±1.0 | 3.9 |
| 2 | 31 | >500 | >1000 | >1000 | - |
| 3 | 32 | 3.2±0.1 | 5.7±0.6 | 50.8±3.7 | 15.8 |
| 4 | 37 | 5.2±0.3 | 19.2±0.8 | 2.1±0.4 | 0.4 |
| 5 | 34 | 28.5±4.6 | 5.6±0.6 | 8.3±1.11 | 0.3 |
