Figure 2.

CVB4 is present in the pancreas of CVB4-infected female wild-type and TLR3 knockout NOD mice. Pancreas was collected from euthanized mice at days 3 and 4 after CVB4 infection, and virus titers were determined. TLR3 knockout NOD mice (n = 3) had significantly (P = .01) more virus than wild-type NOD counterparts (n = 2) at 3 days after infection. This difference was gone by 4 days after infection (n = 2, for each group). Statistical significance was determined using an independent t test. Bar indicates statistical significance between groups with P = .01, as indicated.