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. 2014 Dec 2;156(2):565–575. doi: 10.1210/en.2014-1690

Figure 1.

Figure 1.

mTORC1 activity is diminished in liver of DW and GHR−/− mice. A, Representative Western blots showing the phosphorylation status for S6, S6K, and 4E-BP1 in liver samples from DW and control littermates (WT) under fasting (fasted) or fed (fed) conditions. B, Quantification of pS6, pS6K, and p4E-BP1 phosphorylation ratios from 3 independent experiments. C, Representative Western blots showing the phosphorylation status for S6, S6K, and 4E-BP1 in liver samples from GHR−/− (GH) and control litter mates (WT) under fasted or fed conditions. D, Quantification of pS6, pS6K, and p4E-BP1 phosphorylation ratios. Each bar represents the mean ± SEM from a total of 16 mice (8 females and 8 males) per group and normalized to the ratio found in fasted DW or GHR−/−, respectively, samples. An asterisk indicates statistical significance relative to the fasting DW or GHR−/− from each group.