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. 2015 Jan 14;10:633–644. doi: 10.2147/IJN.S74079

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© 2015 Wang et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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The contour plot (A and B) and corresponding surface response plots (C and D).

Abbreviations: J_ss, steady-state flux; Q₂₄, permeation of rotigotine in 24 hours; S_mix, mixture of Cremophor RH40, Labrofil and Transcutol HP.