Table 6.
Pharmacokinetic parameters of the rotigotine microemulsion gel and Neupro® patch
| Dosing form | t1/2 (h) | Tlag | Tmax (h) | Cmax (ng/mL) | AUC0→48h (μg·h/mL) | Frel (%) |
|---|---|---|---|---|---|---|
| Microemulsion gel | 13.87±4.38 | 0 | 6.67±1.03 | 12.15±3.67 | 179.68±34.85 | 105.76±20.52 |
| Neupro® | 22.35±12.83 | 0 | 7.33±2.42 | 9.83±2.80 | 169.39±30.77 | 100 |
Notes: Each data represents the mean ± SD (n=6).
Abbreviations: AUC, area under the concentration–time curve; Cmax, maximum blood concentration; Frel, relative bioavailability; SD, standard deviation; t½, half-life; Tlag, lag time; Tmax, time to reach Cmax.