Table 4.
Adverse events (grade 3 and 4) according to treatment groups.
| Cisplatin/gemcitabine (N = 771) | Oxaliplatin/gemcitabine (N = 699) | P | |||||
|---|---|---|---|---|---|---|---|
| No. of missing studies | No. of available data | N (%) | No. of missing studies | No. of available data | N (%) | ||
| Asthenia | 12 | 381 | 61 (16) | 8 | 408 | 23 (6) | <0.0001 |
| Nausea | 9 | 500 | 23 (5) | 10 | 331 | 12 (4) | 0.5976 |
| Vomiting | 8 | 538 | 26 (5) | 6 | 519 | 18 (3) | 0.2845 |
| Diarrhea | 10 | 266 | 15 (6) | 8 | 373 | 8 (2) | 0.02919 |
| Peripheral neuropathy | 13 | 176 | 1 (0) | 3 | 543 | 58 (11) | <0.0001 |
| Alopecia | 14 | 295 | 5 (2) | 13 | 97 | 0 (0) | 0.3388 |
| Renal toxicity | 10 | 424 | 7 (2) | 13 | 97 | 0 (0) | 0.358 |
| Hepatotoxicity | 10 | 451 | 49 (11) | 9 | 360 | 24 (7) | 0.04761 |
| Anemia | 5 | 608 | 94 (15) | 8 | 300 | 17 (6) | <0.0001 |
| Thrombopenia | 3 | 661 | 110 (17) | 6 | 473 | 34 (7) | <0.0001 |
| Neutropenia | 4 | 634 | 216 (34) | 7 | 442 | 52 (12) | <0.0001 |
| Mucositis | 13 | 165 | 3 (2) | 11 | 241 | 0 (0) | 0.0664 |
| Febrile neutropenia | 12 | 200 | 8 (4) | 10 | 331 | 13 (4) | 1 |