Figure 1.

(A) Veliparib showed limited single-agent activity across a wide concentration range in a panel of SCLC cell lines. (B) Log of mean ± SEM of IC₅₀ concentrations for cisplatin, carboplatin, and etoposide alone and in combination with 5 and 50 μmol/L concentrations of veliparib. Each bar represents log of the mean value obtained from 3 to 4 independent experiments. Bottom Right: Potentiation of cytotoxicity induced by gamma radiation in the presence of veliparib (5 μmol/L) in 2 representative cell lines (H146 and DMS153).