Figure 5.

(A) Each bar represents mean levels of veliparib detected in plasma or homogenized tumor samples at 1 h and at 24 h posttreatment. Veliparib was rapidly distributed into the intratumoral compartment following oral gavage administration and was <25 ng/mL and <125 ng/g at 24 h in plasma and tissue, respectively. The pharmacokinetic property of veliparib was not significantly altered by coadministration with cisplatin. (B) Each bar represents mean levels of cisplatin detected in plasma or homogenized tumor samples at 1 h and at 24 h posttreatment in replicate mice. Note that cisplatin was no longer detectable in plasma at 24 h under all treatment conditions and that the increased intratumoral platinum observed after coadministration of cisplatin (2.5 mg/kg) and veliparib (25 mg/kg) was comparable to the level achieved with single-agent administration of cisplatin at a higher dose of 5 mg/kg.