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. 2015 Jan 2;179(2):188–196. doi: 10.1111/cei.12447

Figure 1.

Figure 1

Alpha-galactosylceramide (αGalCer) increases anti-tetanus toxoid (TT)-specific antibody production in postnatal day (pnd) 17 neonates. Pnd 7 (a) and pnd 17 (b) neonates were immunized with TT given with and without co-treatment with αGalCer. Plasma TT-specific immunoglobulin (Ig)M levels (enzyme-linked immunosorbent assay) were determined 10 days later. (c) TT-specific IgG for pnd 17 neonates 7 days after secondary immunization. Results represent two independent experiments each with five or six mice per group. Differences from control (TT alone) were determined by Student's t-test, P < 0·05. (d). Representative images of spleen sections (10 μm) after primary immunization stained with anti-IgM-fluorescein isothiocyanate (FITC) (green) and anti-Ki67-phycoerythrin (PE) (red). IgM outlined the follicles and Ki67 stained germinal centre activity (arrow). The number of red cells within the follicle region is noted on each of the representative images.