Table 1.
Median and interquartile range of cytokine levels among children having biopsy-proven coeliac disease and controls (negative for tissue transglutaminase antibodies)
| Cytokine | Coeliac disease (n = 26) | Controls (n = 52) | P-value‡ |
|---|---|---|---|
| (pg/ml) | Median (IQR†) | ||
| IFN-γ | 29·8 (4·1–492·4) | 1·7 (0·5–13·3) | <0·001 |
| IL-5 | 81·7 (18·1–339·1) | 7·1 (1·3–50·7) | <0·001 |
| IL-10 | 3·7 (1·1–17·0) | 0·8 (0–3·7) | 0·001 |
| IL-12p70 | 14·1 (5·7–32·0) | 3·7 (0·9–9·7) | 0·001 |
| IL-13 | 6·3 (2·6–27·4) | 2·5 (0·04–5·7) | 0·002 |
| TNF-α | 15·8 (2·6–260·2) | 95·0 (6·0–2033·2) | 0·100 |
| IL-2 | 17·9 (4·9–88·0) | 67·3 (6·7–421·8) | 0·132 |
| IL-1β | 5·0 (1·7–25·1) | 2·7 (0·8–17·7) | 0·135 |
| IL-4 | 12·5 (4·4–47·8) | 26·9 (7·9–55·1) | 0·185 |
| IL-8 | 2·8 (0·1–9·3) | 4·0 (1·3–11·0) | 0·188 |
†
Interquartile range.
‡
Mann–Whitney U-test for differences in distribution between two independent samples. IL = interleukin; IFN = interferon; TNF = tumour necrosis factor.