Figure 3.

Complement activation capacity at five predetermined time-points in patients undergoing cardiopulmonary bypass with Phisio®- (n = 15) or Bioline®-coated circuits (n = 15). Deposition of terminal complement complex (TCC) via the ficolin-3 pathway (FCN3) (a), the lectin [mannose-binding lectin (MBL)] pathway (b), the classical pathway (CP) (c) and alternative pathway (AP) (d) all displayed a significant drop in activity from T0 to T1, but normalized after 24 h (T4). C3a (e) and soluble TCC (f) were at a minimum at T0 and then increased significantly to T1. For both factors the serum concentration peaked at T2, and levels had normalized 24 h postoperatively.