Table 3.
Multivariable logistic and Cox regression analysis – independent predictors of progressive state of kidney disease
| Variables |
Logistic regression |
Cox regression |
||
|---|---|---|---|---|
| Odds ratio (95% CI) | P | Hazard ratio (95% CI) | P | |
| Clinical and pathological parameters | ||||
| eGFR | 0·96 (0·93–0·99) | 0·018 | 0·95 (0·93–0·98) | <0·0005 |
| Proteinuria (g/day) | 1·26 (0·75–2·13) | 0·379 | 1·19 (0·93–1·54) | 0·172 |
| T1–2 score | 8·72 (1·64–46·40) | 0·011 | 4·37 (1·19–16·1) | 0·027 |
| Immunohistological biomarkers | ||||
| High TGase-2 T score | 7·95 (0·97–64·84) | 0·053 | 3·88 (1·03–14·6) | 0·045 |
| C4d positivity | 7·68 (1·176–50·132) | 0·033 | 3·68 (1·3–10·43) | 0·014 |
| CD3 score* | 1067 (1027–1109) | 0·001 | 10017 (1007–1027) | 0·001 |
| Clinical, pathological and immunohistological biomarkers | ||||
| eGFR | 0·96 (0·925–0·991) | 0·012 | 0·95 (0·929–0·975) | <0·0005 |
| C4d positivity | 9·29 (1·18–73·25) | 0·034 | 3·35 (1·25–8·95) | 0·016 |
| CD3 score* | 1005 (1016–1096) | 0·006 | 1016 (1006–1026) | 0·003 |
*CD3 score – per 1000-units increment. T1–2 according to the Oxford classification reanalysis of the biopsies. High TGase-2 T score (>25% staining). CI = confidence interval; eGFR = estimated glomerular filtration rate.