Table 1.
Fold change of miRs deregulated in PCCl3 rat thyroid cells treated with TGF03B2;, Akti-1/2, or 17-AAG compared with DMSO vehicle control
| Rat miRs | TGFβ/DMSO | Akti-1/2/ DMSO |
17-AAG/DMSO |
|---|---|---|---|
| rno-miR-3578 | −1.6 | −2.1 | −1.2 |
| rno-miR-465 | −1.6 | −1.9 | 1.0 |
| rno-miR-3571 | 1.1 | −2.2 | −1.4 |
| rno-miR-344a-3p | 1.1 | −1.9 | −1.2 |
| rno-miR-3589 | 1.0 | −1.9 | −1.1 |
| rno-miR-449c-3p | −2.1 | −2.0 | −1.4 |
| rno-miR-3594-3p | −1.3 | −1.8 | −1.4 |
| rno-miR-455 | −1.1 | −1.8 | −1.1 |
| rno-miR-532-5p | −1.2 | −1.8 | −1.4 |
| rno-miR-325-3p | 1.0 | −1.8 | −1.3 |
| rno-miR-301a | −1.2 | 1.5 | 1.4 |
| rno-miR-29a | 1.0 | 1.4 | 1.2 |
| rno-miR-29c | −1.2 | 1.6 | 1.6 |
| rno-miR-3585-5p | 1.0 | 1.4 | 1.7 |
| rno-miR-218a | 1.3 | 1.6 | 1.4 |
| rno-miR-29b | −1.1 | 2.0 | 1.9 |
| rno-miR-331 | −1.3 | −1.8 | −2.9 |
| rno-miR-872 | −1.2 | −1.4 | −2.0 |
| rno-miR-106b | 1.4 | −1.1 | 1.4 |
| rno-miR-425 | 1.3 | 1.2 | 1.4 |
| rno-miR-30c | 1.0 | 1.1 | 1.4 |
| rno-miR-96 | 1.0 | 1.6 | 1.7 |
| rno-miR-30b-5p | −1.3 | 2.3 | 2.7 |
| rno-miR-190b | −1.1 | −1.3 | 1.5 |
| rno-miR-3559-5p | −1.4 | 1.1 | 1.6 |
| rno-miR-1949 | −2.1 | −1.7 | −1.3 |
| rno-miR-3581 | −2.0 | −1.6 | −1.4 |
| rno-miR-374 | −1.8 | −1.5 | −1.8 |
| rno-miR-544 | −1.8 | −1.9 | −1.4 |
| rno-miR-3561-3p | 1.4 | −1.5 | 1.2 |
| rno-miR-206 | 1.4 | 1.1 | 1.1 |
| rno-miR-27b | 1.4 | −1.0 | 1.1 |
| rno-miR-322 | 1.4 | 1.2 | 1.1 |
| rno-miR-539 | 1.7 | 1.0 | −1.1 |
| rno-miR-148b-3p | 1.4 | 1.5 | 1.6 |
| rno-miR-15b | 1.4 | 1.5 | 1.9 |
| rno-miR-195 | 1.4 | 1.3 | 1.3 |
| rno-miR-23b | 1.7 | 1.3 | 1.2 |
Fold changes highlighted in bold are significantly upregulated more than 1.4-fold or significantly downregulated more than 1.8-fold. miRs high-lighted in italics are conserved between rats and humans. miRs underlined are predicted to bind to the 3′UTR of rNis. miRs highlighted in bold are predicted to bind to the 3′UTR of hNIS.