Plots A and B: Cluster plots for a responsive tumor. From baseline (Plot A) to mid-cycle (Plot B), the VFs of clusters 1, 2, 3 change from 69% to 60% (decrease), from 7% to 37% (increase), from 24% to 3% (decrease), respectively.
Plots C and D: Cluster plots for a non-responsive tumor. From baseline (Plot C) to mid-cycle (Plot D), the VFs of clusters 1, 2, 3 change from 35% to 56% (increase), from 43% to 18% (decrease), from 22 to 26% (increase), respectively.