TABLE 1.
Performance characteristics of three rapid tests for detecting RSV-A/-B compared to those of RT-PCRa
| RSV type | Rapid test usedb | Sensitivity (% [no./total no., 95% CI])c | Specificity (% [no./total no., 95% CI]) | Positive predictive value (% [no./total no., 95% CI]) | Negative predictive value (% [no./total no., 95% CI]) | Positive likelihood ratio (95% CI)d | Negative likelihood ratio (95% CI) |
|---|---|---|---|---|---|---|---|
| A | SO | 66 (64/97, 56.6–75.4) | 98.0 (246/251, 95.4–99.1) | 92.8 (64/69, 84.1–96.9) | 81.5 (145/178, 75.1–86.5) | 19.8 (8.3–47.4) | 0.35 (0.27–0.47) |
| BN | 65 (63/97, 55.4–74.4) | 100.0 (251/251, 98.5–100.0) | 100.0 (63/63, 94.3–100.0) | 81.5 (150/184, 75.3–86.5) | NA | 0.35 (0.27–0.46) | |
| SD | 64 (62/97, 54.3–73.5) | 100.0 (251/251, 98.5–100.0) | 100.0 (62/62, 94.2–100.0) | 81.1 (150/185, 74.8–86.1) | NA | 0.36 (0.28–0.47) | |
| B | SO | 71 (72/101, 62.5–80.1) | 98.0 (242/247, 95.3–99.1) | 93.5 (72/77, 85.7–97.2) | 83.3 (145/174, 77.1–88.1) | 21.4 (9.0–51.1) | 0.30 (0.22–0.40) |
| BN | 63 (64/101, 54.0–72.8) | 100.0 (247/247, 98.5–100.0) | 100.0 (64/64, 94.3–100.0) | 80.2 (150/187, 73.9–85.3) | NA | 0.37 (0.28–0.47) | |
| SD | 65 (66/101, 56.1–74.6) | 100.0 (247/247, 98.5–100.0) | 100.0 (66/66, 94.5–100.0) | 81.1 (150/185, 74.8–86.1) | NA | 0.35 (0.27–0.45) |
a
RSV, respiratory syncytial virus; RT-PCR, real-time reverse transcription-PCR.
b
SO, Sofia RSV FIA kit; BN, BinaxNOW RSV card kit; SD, SD Bioline RSV kit.
c
CI, confidence interval.
d
The positive likelihood ratio was not applicable (NA) when the denominator was zero.