TABLE 4.

Test results and demographic and clinical information for patients with serially collected CSF samples^a

Patient no., sex,b age (yr), and LPc date (day, mo, yr)	Result of:			CT	No. of WBCd/ml	Mean BDG level (pg/ml) ± SDe	Clinical outcome
	Culture	PCR	Real-time PCR
1, F, 42
17 Oct. 2012	Negf	E. rostratum	E. rostratum	33	2,507	NPg	Multiple strokes, deceased
7 Nov. 2012	Neg	Neg	Neg	0	1,330	>500
10 Dec. 2012	Neg	Neg	Neg	0	104	NP
15 Jan. 2013	Neg	Neg	Neg	0	57	>500
2, F, 64
7 Oct. 2012	Neg	Neg	Indh	43	2,576	>500	Relapse meningitis, on retreatment, stable
7 Nov. 2012	Neg	Neg	Neg	0	177	>500
6 Feb. 2013	Neg	Neg	Neg	0	0	>500
16 May 2013	Neg	C. cladosporioides	Neg	0	513	>500
30 May 2013	Neg	Neg	Neg	0	145	>500
3,i M, 80
4 Oct. 2012	Neg	Neg	E. rostratum	38	119	>500	Relapse meningitis, on treatment, stable
17 Oct. 2012	Neg	Neg	Neg	0	63	>500
30 Nov. 2012	Neg	Neg	Neg	0	9	488 ± 11
11 Jan. 2013	Neg	Neg	Neg	0	5	246 ± 75
11 Mar. 2013	Neg	E. rostratum	E. rostratum	36	2,075	>500
4, F, 77
9 Oct. 2012	Neg	E. rostratum	E. rostratum	30	2,550	>500	Relapse soft tissue phlegmon, on retreatment, stable
8 Nov. 2012	Neg	Neg	E. rostratum	40	34	>500
5 Dec. 2012	Neg	Neg	E. rostratum	38	0	>500
5, M, 72
5 Oct. 2012	Neg	E. rostratum	E. rostratum	34	1,989	>500	Completed treatment, asymptomatic, stable
19 Dec. 2012	Neg	Neg	E. rostratum	39	5	>500
13 Feb. 2013	Neg	Neg	Neg	0	2	387 ± 33
3 Apr. 2013	Neg	Neg	Neg	0	7	218 ± 4
6, M, 69
4 Oct. 2012	Neg	Neg	E. rostratum	33	664	>500	Completed treatment, asymptomatic, stable
5 Dec. 2012	Neg	Neg	Neg	0	14	>500
6 Mar. 2013	Neg	Neg	Neg	0	0	383 ± 32
7, F, 64
11 Oct. 2012	Neg	E. rostratum	E. rostratum	30	3,996	>500	Completed treatment, asymptomatic, stable
25 Oct. 2012	Neg	Neg	Ind	41	43	NP
2 Jan. 2013	Neg	Neg	Neg	0	7	>500
6 Feb. 2013	Neg	Neg	Ind	44	5	438 ± 23
8 Apr. 2013	Neg	Neg	Neg	0	5	408 ± 32
15 Jul. 2013	Neg	Neg	Neg	0	3	252 ± 103
8, M, 44
15 Oct. 2012	Neg	E. rostratum	E. rostratum	39	602	NP	Completed treatment, asymptomatic, stable
28 Nov. 2012	Neg	Neg	Neg	0	85	>500
4 Jan. 2013	Neg	Neg	Neg	0	7	>500
25 Feb. 2013	Neg	Neg	Neg	0	14	391 ± 14
1 Apr. 2013	Neg	Neg	Neg	0	5	457 ± 61
6 May 2013	Neg	Neg	Neg	0	8	<32
9, F, 75
22 Oct. 2012	E. rostratum	E. rostratum	E. rostratum	31	NP	NP	Completed treatment, asymptomatic, stable
12 Nov. 2012	Neg	Neg	Ind	44	3,106	>500
23 Nov. 2012	Neg	Neg	Ind	43	10	412 ± 3
1 Feb. 2013	Neg	Neg	Ind	42	14	238 ± 2
8 Mar. 2013	Neg	Neg	Neg	0	2	120 ± 25
10, F, 84
4 Oct. 2012	Neg	Neg	E. rostratum	34	2,676	>500	Continues on treatment (8 mo), stable
21 Nov. 2012	Neg	Neg	Neg	0	66	>500
1 Mar. 2013	Neg	Neg	Neg	0	17	>500
5 Apr. 2013	E. nigrum	Neg	Neg	0	157	427 ± 35
26 Apr. 2013	Neg	Neg	Neg	0	48	240 ± 14
28 May 2013	Neg	Neg	Neg	0	43	<32
11, M, 65
4 Oct. 2012	Neg	E. rostratum	E. rostratum	28	1,828	>500	Completed treatment, asymptomatic, stable
2 Nov. 2012	Neg	Neg	Neg	0	71	235 ± 17
9 Jan. 2013	Neg	Neg	Neg	0	2	<32
7 Feb. 2013	Neg	Neg	Neg	0	0	41 ± 9
8 May 2013	Neg	Neg	Neg	0	0	<32
12, F, 58
29 Sep. 2012	C. cladosporioides	Neg	Neg	0	9,080	>500	Completed treatment, asymptomatic, stable
22 Oct. 2012	Neg	Neg	Neg	0	173	NP
21 Dec. 2012	Neg	Neg	Neg	0	2	112 ± 5
21 Mar. 2013	Neg	Neg	Neg	0	7	55
13, M, 77
8 Oct. 2012	Neg	E. rostratum	E. rostratum	30	1,530	>500	Completed treatment, asymptomatic, stable
9 Nov. 2012	Neg	Neg	Ind	42	6,373	>500
3 Jan. 2013	Neg	Neg	Neg	0	65	>500
5 Feb. 2013	Neg	Neg	Neg	0	5	104 ± 0
5 Apr. 2013	Neg	Neg	Neg	0	17	129 ± 21
20 Apr. 2013	Neg	Neg	Neg	0	7	45 ± 0
14, M, 50
4 Oct. 2012	E. rostratum	E. rostratum	E. rostratum	32	830	>500	Continues on treatment (8 mo),stable
8 Nov. 2012	Neg	Neg	Neg	0	418	>500
18 Dec. 2012	Neg	Neg	Neg	0	121	>500
12 Mar. 2013	Neg	Neg	Neg	0	50	32 ± 61
3 Jun. 2013	Neg	Neg	Neg	0	16	335
5 Aug. 2013	Neg	Neg	Neg	0	157	385 ± 25
15, M, 70
5 Oct. 2012	Neg	Neg	E. rostratum	39	2,610	>500	Completed treatment, asymptomatic, stable
8 Nov. 2012	Neg	Neg	Neg	0	7	297 ± 20
12 Dec. 2012	Neg	Neg	Neg	0	2	241 ± 18
6 Feb. 2013	Neg	Neg	Neg	0	0	69 ± 12
5 Apr. 2013	Neg	Neg	Neg	0	0	123 ± 2
16, M, 61
8 Oct. 2012	Neg	Neg	Ind	43	280	>500	Completed treatment, asymptomatic, stable
12 Nov. 2012	Neg	Neg	Neg	0	52	385 ± 75
5 Dec. 2012	Neg	Neg	Neg	0	0	41 ± 1
4 Mar. 2013	Neg	Neg	Neg	0	0	<32
10 May 2013	Neg	Neg	Neg	0	0	<32
17, F, 55
24 Oct. 2012	Neg	E. rostratum	E. rostratum	34	48	>500	Completed treatment, asymptomatic, stable
28 Nov. 2012	E. nigrum	Neg	E. rostratum	38	954	>500
23 Jan. 2013	Neg	Neg	Ind	41	0	110 ± 4
1 Apr. 2013	Neg	Neg	Neg	0	2	50 ± 4
18, F, 92
15 Oct. 2012	Neg	Neg	E. rostratum	36	28	486 ± 20,124	Completed treatment, asymptomatic, stable
19 Nov. 2012	Neg	Neg	Neg	0	2	426 ± 269
22 Jan. 2013	Neg	Neg	Ind	42	5	278 ± 11
1 May 2013	Neg	Neg	Neg	0	2	266 ± 14
19, M, 16
29 Oct. 2012	Neg	E. rostratum	E. rostratum	30	710	450 ± 14	Completed treatment, asymptomatic, stable
12 Dec. 2012	Neg	Neg	Neg	0	90	>500
21 Jan. 2013	Neg	Neg	Neg	0	12	171 ± 52
17 May 2013	Neg	Neg	Neg	0	6	<32
20, F, 63
11 Oct. 2012	Neg	Neg	E. rostratum	39	777	>500	Completed treatment, asymptomatic, stable
30 Oct. 2012	Neg	Neg	Neg	0	475	>500
18 Feb. 2013	Neg	Neg	Neg	0	33	280 ± 8
15 May 2013	Neg	Neg	Neg	0	5	296 ± 18

^aOnly lumbar punctures with culture, PCR assay, and/or BDG results are included.

^bF, female; M, male.

^cLP, lumbar puncture. Lumbar puncture dates for patients 1, 4, 8, and 9 were adjusted compared to a previous report (6) based on clinical data review.

^dWBC, white blood cells.

^eMean values and standard deviations of three readings are shown. The CSF BDG positive cutoff was determined to be 138 pg/ml (6).

^fNeg, negative.

^gNP, not performed.

^hInd, indeterminate.

ⁱReference 12.