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. 2015 Jan 23;53(2):557–566. doi: 10.1128/JCM.02735-14

FIG 3.

FIG 3

Optimal cutoff P/N value, sensitivity, and specificity of NS1-MAC/GAC-ELISAs. Optimal cutoff value was determined by the magnitude of positive likelihood ratio (LR+) calculated by dividing sensitivity by 100 − specificity. (A) Example plot of sensitivity versus 100 − specificity of both MAC-ELISA (left panel) and GAC-ELISA (right panel) based on P/N ratio values from 54 DENV-confirmed convalescent-phase sera and 66 control sera. (B and C) Sensitivity and specificity of NS1-MAC-ELISA (left panels) and NS1-GAC-ELISA (right panels) based on the optimal cutoff P/N value obtained from 54 DENV-confirmed acute-phase (B) and convalescent-phase (C) sera and 66 control sera.