Table 1.
Association of rs340874 PROX1 genotypes with demographic, anthropometric, behavioral (food intake and physical activity) data and laboratory measurements at fasting state
| Parameter | CC | CT | TT |
|---|---|---|---|
| N | 246 | 442 | 257 |
| Age (years) | 42.6 ± 0.9 | 39.3 ± 0.7 | 40.0 ± 0.9 |
| Gender (% male) | 48.8 | 48.9 | 55.6 |
| BMI | 29.0 ± 0.5 | 28.0 ± 0.3 | 28.1 ± 0.4 |
| WHR | 0.93 ± 0.005 | 0.93 ± 0.004 | 0.93 ± 0.005 |
| Fat content (%) | 30.7 ± 0.8 | 29.1 ± 0.6 | 28.5 ± 0.8 |
| VAT (cm3)* | 114.4 ± 6.8 | 96.1 ± 4.0 | 94.1 ± 5.4 |
| VAT/SAT | 0.70 ± 0.04 | 0.63 ± 0.02 | 0.62 ± 0.03 |
| Insulin fasting (IU/ml) | 13.8 ± 1.0 | 12.5 ± 0.5 | 12.5 ± 0.7 |
| Fasting glucose (mg/dl) | 98.5 ± 0.7 | 96.5 ± 1.6 | 95.3 ± 1.0 |
| HOMA-B | 163.0 ± 13.3 | 163.9 ± 8.5 | 149.3 ± 16.3 |
| HOMA-IR | 3.4 ± 0.3 | 3.1 ± 0.1 | 3.1 ± 0.2 |
| Total energy intake (kcal/day)† | 1,736 ± 54 | 1,846 ± 51 | 2,053 ± 67 |
| Carbohydrate intake (g/day)‡ | 223 ± 6 | 232 ± 6 | 262 ± 9 |
| Protein intake (g/day) | 80 ± 2§ | 85 ± 2 | 94 ± 3 |
| Fat intake (g/day) | 61 ± 3 | 66 ± 3 | 70 ± 3 |
| Food energy density | 0.86 ± 0.03 | 0.87 ± 0.02 | 0.89 ± 0.03 |
| Physical activity (MET) | 10,056 ± 562 | 9,616 ± 394 | 10,422 ± 568 |
Values are mean ± SE, unless otherwise indicated
Significant p values are presented: * p < 0.02, † p < 0.001, ‡ p < 0.002, § p < 0.01