Table 2.

Clinical Grading of Sinusoidal Obstruction Syndrome.^a

	Mild	Moderate	Severe
Bilirubin, mg/dL	<5	5.1–8.0	>8.0
Liver enzymes (AST, ALT)	<3X normal	3–8X normal	>8X normal
Weight above baseline	<2%	2–5%	>5%
Serum creatinine	Normal	<2X normal	>2X normal
Clinical rate of change	Slow	Moderate	Rapid

AST, aspartate transferase. ALT, alanine transferase.

^aPer reference. ⁶²