Table 1. Guidelines to recommend and offer FXS genetic testing.

	Recommend Genetic Testing	Offer Genetics Testing
Women	Premature ovarian insufficiency Women who request fragile X prenatal carrier screening	Family history of POI and mood/anxiety disorder Family history fibromyalgia and mood/anxiety disorder Prenatal testing by amniocentesis or CVS for known PMC
All Adults	Intellectual Disability (ID) Autism Spectrum Disorder (ASD) Family history of ID or ASD Family history of FXS Unexplained late onset tremor and ataxia	Late onset dementia associated other premutation disorders Family history of undiagnosed dementia or parkinsonism associated other premutation disorders “MCP sign” or white matter lesions in the cerebral white matter on MRI