Fig. 1.

Frequencies of inherited mutations in breast cancer genes among African American breast cancer patients with young age at diagnosis, family history of breast or ovarian cancer, or triple negative breast cancer (TNBC). a Numbers of patients meeting each of the study criteria. All patients were diagnosed with primary invasive breast cancer and self-identified as African American. FH+ indicates a first or second degree relative with breast cancer diagnosed at age <60 or ovarian cancer at any age; Br/Ov indicates breast and ovarian cancer in the same subject; Br dx <45 indicates that the participant’s breast cancer was diagnosed at age <45; TNBC indicates that the breast cancer was triple negative; i.e., lacking estrogen and progesterone receptors and Her2. The study included 289 patients in all. b Proportions of patients with an unequivocally damaging mutation in a breast cancer gene, for each group from (a)