Fig. 1.

Representative core with invasive tumor and non-neoplastic tissue (core 19); 25 % cellularity estimated by author S.K. in histologic image (standard H&E staining), 30 % cellularity estimated in grayscale confocal fluorescence image (0.01 % proflavine staining), and 25 % cellularity estimated in false-colored confocal fluorescence image derived from grayscale image (0.01 % proflavine staining). The solid outlined region indicates areas of the CNB specimen that contain invasive tumor. The scale bar at left is 750 μm. The insets at right show the border between neoplastic and non-neoplastic tissue in the CNB specimen. The locations of the insets are indicated in each core by a square with dashed lines. The scale bar at right is 100 μm