Figure 4. Real-time reporting of circadian expression of PER2::LUC in the forebrain/SCN knockout mice.
(A) Representative records of bioluminescence reporting of circadian expression from various tissues in Fx/Fx and BKO mice. Tissues were prepared from mice in LD. PMT counts are plotted against the LD cycle of day 1. Shown are 10 days of continuous recording after explant preparation, except for the SCN for which medium was changed on day 12. (B, C) Period plots of various tissues harvested from Fx/Fx control (open circle) and BKO (dark circle) mice in LD (B) and DD (C). The sample size is indicated on right. Shown are mean period ± SD. **p < 0.01, ****p < 0.0001 by t-test.