FIG. 3.

Beneficial effects of iminosugar feeding on glucose metabolism in ob/ob mice. ob/ob mice were fed either a control diet (○ and □) or with diet providing a dose of 25 mg AMP-DNM · kg body wt⁻¹ · day⁻¹ (● and ■). Body weight (A) and blood glucose levels (B) were determined at indicated time points. During the clamp, glucose infusion rate (GIR) was monitored (C), the rate of glucose disposal [Rd(glc)], and the rate of endogenous hepatic glucose production [Ra(glc;endo)] were calculated (D). Data presented are means ± SD. Significant differences between both groups (*) are indicated. Statistical significances of differences were determined using Student’s t test, except in calculations over time where ANOVA with repeated measurements was used. P < 0.05 was considered statistically significant.