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. 2015 Jan 20;5:7906. doi: 10.1038/srep07906

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a, RMSD analysis of loop_3-4 in the closed-to-open cMD simulation with biotin binding.Black line indicates the RMSD of loop_3-4 based on the alignment of the entire protein. Red line shows the RMSD of loop_3-4 based on the alignment of the loop_3-4. b, the changes of the distances between the center mass of the loop_3-4 and biotin plotted as a function of time in the closed-to-open cMD simulation.