Table 1. Summary of Conventional MD (cMD) and Accelerated MD (aMD) simulation.

Bio-system	Simulation length (ns)		Biotin binding	Constant c
Monomer	cMD	aMD
Open-close	300	200	No	0.4
Close-open	500	120	No	0.4
Close-open	300	300	Yes	0.4
Change loop	100	/	Yes	0.4
Tetramer
Open-close	/	800	No	0.5