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. 2015 Jan 20;5:7886. doi: 10.1038/srep07886

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This model summarizes the different processes of DNA replication in which Rad53 regulation is involved. The replication forks activate the sensor kinase Mec1, which then phosphorylates the downstream kinase Rad53. Rad53 works through phosphorylation of Sld3 and Dbf4 to inhibit late origin firing. Rad53 works through inhibition of Exo1 to stabilize replication forks and through Ixr1 and Dun1-dependent induction and activation of RNR to promote fork restart.