Table IV.

Relevant PK parameters of GTI-2040 (mean ± SD).

Parameter	3.5 mg/kg/day* (n = 3)	5.0 mg/kg/day (n = 9)	7.0 mg/kg/day (n = 3)
Css (nM)	269±111	396±200	430±44.4
AUC 0–∞ (μM×h)	46.1±20.5	57.3±30.5	76.9±10.9
CL (L/h)	9.62±7.61	10.2±6.80	8.93±1.40
Vss (L)	8.71±5.69	27.7±22.2	14.6±4.02
t1/2α (h)	0.670±0.150	0.900±0.290	0.773±0.162
t1/2β (h)		32.1±16.2	16.7±4.42

C_ss, steady-state concentration; AUC, area under the curve; CL, clearance; V_ss, steady-state volume; t_1/2α, redistribution half-life; t_1/2β, elimination half-life.

^*Samples of three patients were only collected to 4 h after the end of infusion; data were fitted by one-compartment model.