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. 2014 Apr 22;40(4):489–501. doi: 10.1111/nan.12056

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© 2013 The Authors. Neuropathology and Applied Neurobiology published by John Wiley & Sons Ltd. on behalf of British Neuropathological Society.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Immunohistochemistry for PtdIns(4,5)P2. Immunohistochemistry in AD, MyD, ALS and control cases. AD case (case 1): low-power fields in hippocampus (a,b) and neocortex (c). MyD case (case 6): low-power fields in hippocampus (d,e) and neocortex (f). ALS case (case 17): low-power fields in hippocampus (g,h) and neocortex (i). Control case (case 26): low-power fields in hippocampus (j,k) and neocortex (l). AD case (case 5): some of the detected structures are (m) GVD bodies, (n) ‘GVD bodies + NFTs’, and (o) NFTs. The specificity of immunoreactivity for PtdIns(4,5)P2 was verified using PLCδ₁PH-GST on sections, which showed essentially the same staining pattern as the anti-PtdIns(4,5)P2 antibody (p–r). Scale bars: (a–l) 50 μm, (m–r) 20 μm.