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. 2014 Apr 10;44(6):1759–1769. doi: 10.1002/eji.201344265

Figure 1.

Figure 1

Changes in the numbers of circulating CD4+ and CD8+ T cells after fludrocortisone administration. Naive (CD45RA+CD62L+), central memory (CD45RA−CD62L+), effector memory (CD45RA−CD62L−) and effector (CD45RA+CD62L−) CD4+ (left) and CD8+ (right) T-cell counts were determined in whole blood by flow cytometry before (−1.5 and 0 h) and between 1.5 and 8.25 h after oral administration of fludrocortisone (0.2 mg) or placebo. Values for the fludrocortisone condition are indicated as difference from the placebo condition to eliminate the well-known strong circadian variation in T-cell numbers. Data are expressed as mean ± SEM of 13 healthy male subjects. All values are adjusted to baseline measures (i.e., the first two samples before drug administration) based on covariance analyses. *p < 0.05, **p < 0.01, for pairwise comparisons between the effects of fludrocortisone and placebo at single time points (paired t-tests). See text for ANOVA results.