Table 2.
Genes selected from the “before IR” and “after IR” analysis
| Selected genes from “before”/“after” analysis | ||||||
|---|---|---|---|---|---|---|
| BCAN | CTSA | PDCD1 | ||||
| Before IR | After IR | Before IR | After IR | Before IR | After IR | |
| Normal | 30% | 14% | 35% | |||
| Good response | 64% | 39% | 52% | 34% | 52% | 39% |
| Poor Response | 78% | 71% | 73% | 60% | 63% | 54% |
| p-Value | 0.230 | 0.016 | 0.041 | 0.041 | 0.062 | 0.023 |
| LTC4S | BNIPL | FGFBP2 | ||||
| Before IR | After IR | Before IR | After IR | Before IR | After IR | |
| Normal | 36% | 55% | 19% | |||
| Good response | 56% | 41% | 37% | 57% | 24% | 41% |
| Poor Response | 71% | 63% | 31% | 43% | 19% | 28% |
| p-Value | 0.023 | 0.033 | 0.398 | 0.183 | 0.477 | 0.213 |
| IL5RA | PCK1 | TPRG1 | ||||
| Before IR | After IR | Before IR | After IR | Before IR | After IR | |
| Normal | 54% | 40% | 34% | |||
| Good response | 34% | 49% | 27% | 43% | 35% | 52% |
| Poor Response | 19% | 32% | 16% | 24% | 29% | 41% |
| p-Value | 0.023 | 0.083 | 0.109 | 0.026 | 0.423 | 0.327 |
| RB1 | H2AFY | GYPE | ||||
| Before IR | After IR | Before IR | After IR | Before IR | After IR | |
| Normal | 75% | 18% | 57% | |||
| Good response | 82% | 76% | 60% | 40% | 52% | 65% |
| Poor Response | 86% | 81% | 76% | 61% | 40% | 50% |
| p-Value | 0.035 | 0.118 | 0.037 | 0.076 | 0.056 | 0.021 |
The table shows the percentage of methylation in three groups (poor and good responders in addition to normal controls). The p-value was calculated by using a Mann–Whitney U-test comparing two categories (good response to poor response) both before and after IR. Statistically significant p-values (p < 0.05) are highlighted with bold letters.