Table 4.

Association of total number of siblings with symptoms in subjects with and without the relevant disease label

	Total siblings (per additional sibling) Subjects with relevant disease label ever		Total siblings (per additional sibling) Subjects without relevant disease label ever		Comparison of trends for subjects with and without relevant disease label
OR (95% CL)	P value	OR (95% CL)	P value	P value
Symptom (6 to 7-year-olds)
Wheeze in last 12 months	1.02 (0.98, 1.06)	0.36	0.98 (0.96, 1.01)	0.22	0.14
Severe wheeze in last 12 months	1.07 (1.03, 1.12)	0.0009	1.10 (1.05, 1.15)	< 0.0001	0.39
Rhinoconjunctivitis in last 12 months	1.00 (0.97, 1.04)	0.89	1.04 (1.01, 1.07)	0.01	0.14
Severe rhinoconjunctivitis	1.11 (1.02, 1.21)	0.01	1.06 (0.94, 1.19)	0.34	0.49
Itchy flexural rash in last 12 months	1.06 (1.02, 1.10)	0.001	1.02 (0.99, 1.05)	0.22	0.11
Severe itchy flexural rash	1.22 (1.13, 1.32)	< 0.0001	1.24 (1.13, 1.35)	< 0.0001	0.87
Symptom (13 to 14-year-olds)
Wheeze in last 12 months	1.01 (0.98, 1.05)	0.55	1.02 (0.99, 1.04)	0.21	0.83
Severe wheeze in last 12 months	1.08 (1.04, 1.12)	< 0.0001	1.11 (1.07, 1.14)	< 0.0001	0.28
Rhinoconjunctivitis in last 12 months	1.04 (1.01, 1.07)	0.02	1.03 (1.01, 1.06)	0.009	0.78
Severe rhinoconjunctivitis	1.07 (1.01, 1.15)	0.03	1.07 (0.99, 1.16)	0.09	0.97
Itchy flexural rash in last 12 months	1.06 (1.02, 1.10)	0.003	1.05 (1.02, 1.08)	0.002	0.71
Severe itchy flexural rash	1.11 (1.04, 1.19)	0.003	1.19 (1.11, 1.28)	< 0.0001	0.13

Relevant disease label: asthma ever (for wheeze symptoms), hay fever ever (for rhinitis symptoms), eczema ever (for itchy rash symptoms).