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. 2014 Jun 2;233(4):368–379. doi: 10.1002/path.4363

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© 2014 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Target genes of miRNA-519a co-operatively regulate tamoxifen resistance. Inhibiting individual (a) and combinations (b) of the TSGs using siRNAs in WT cells promotes resistance to tamoxifen after 72 h. Results are shown as an average of three biological and three technical replicates, with significance levels explained in Figure 1. (c) Random survival forests (RSF) analysis of 632 (d) and 586 breast cancer patients who had received hormone therapy (HT) ³⁰ reveals a significant correlation between survival and expression of target genes.