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. 2014 Jun 2;233(4):368–379. doi: 10.1002/path.4363

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© 2014 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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miRNA-519a reduces tamoxifen-induced apoptosis. (a) Caspase activity is elevated only in WT cells after 3 h treatment with 10 µm tamoxifen. (b) Caspase activity is increased only in miR-control transfected cells and is abrogated by transfection with a miRNA-519a mimic. (c) PI staining reveals that more apoptotic cells are present in miR-control than in miRNA-519a mimic-transfected cells after 72 h treatment with tamoxifen. (d) Caspase activity is increased only in inhibitor 519a-transfected TamR cells. The results are presented as an average of two biological and three technical replicates each, with significance levels explained in Figure 1.