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. 2014 Apr 2;103(6):1701–1710. doi: 10.1002/jps.23964

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© 2014 The Authors. Journal of Pharmaceutical Sciences published by Wiley Periodicals, Inc. and the American Pharmacists Association

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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(a) Primary structure of IgG1, IgG2, and IgG4 hinge regions (Kabat numbering¹⁴). (b) T_m measured by DSF and (c) R_h measured by DLS at various pH values and by inclusion of various excipients. IgG1 (blue), IgG2 (red), and IgG4 (green). DLS measurements were performed on stressed samples that were stored at 40°C for 4 days.