Table 2.
Common treatment-related toxic effects
| Toxicity | Grade 1 | Grade 2 | Grade 3 | Grade 4 | Grade 5 |
|---|---|---|---|---|---|
| Gastrointestinal | |||||
| Diarrhea | 13 | 1 | |||
| Nausea | 8 | 3 | |||
| Vomiting | 2 | 1 | |||
| Abdominal pain | 2 | ||||
| Abdominal distension | 1 | ||||
| Flatulence | 2 | 1 | |||
| Neuro/psychiatric | |||||
| Confusion | 2 | 1 | |||
| Dizziness | 5 | ||||
| Cognitive disturbance | 1 | ||||
| Depressed level of consciousness | 1 | ||||
| Dysphasia | 1 | ||||
| Headache | 1 | 4 | |||
| Memory impairment | 3 | ||||
| Peripheral sensory neuropathy | 2 | ||||
| Tinnitus | 8 | ||||
| Tremor | 4 | ||||
| General | |||||
| Anorexia | 2 | ||||
| Chills | 1 | ||||
| Fatigue | 7 | 3 | |||
| Fever | 2 | 1 | |||
| Flu-like symptoms | 1 | ||||
| Multiorgan failure | 1 | ||||
| Weight loss | 2 | 1 | |||
| Investigational | |||||
| Increased ALT | 4 | 5 | 1 | ||
| Increased AST | 8 | 3 | |||
| Increased alkaline phosphatase | 2 | 1 | |||
| Increased bilirubin | 1 | ||||
| Anemia | 2 | 1 | |||
| Hypoglycemia | 1 | ||||
| Hyperglycemia | 5 | 2 | 4 | 1 | |
| High cholesterol | 6 | 1 | 1 | ||
| High creatinine | 1 | ||||
| Hypertriglyceridemia | 6 | 2 | |||
| Hypoalbuminemia | 1 | ||||
| Hyponatremia | 1 | ||||
| Hypophosphatemia | 1 | ||||
| Lymphopenia | 1 | ||||
| Platelet count decreased | 2 | ||||
| Other | |||||
| Allergic reaction | 1 | ||||
| Dehydration | 1 | ||||
| Generalized muscle weakness | 2 | ||||
| Hematuria | 2 | ||||
| Hypotension | 1 | ||||
| Injection site reaction | 1 | ||||
| Nail loss | 1 | ||||
| Pruritus | 2 | ||||
| Maculopapular rash | 3 | 1 | |||