Table 1.
OAR doses for all head and neck patients including parameningeal primaries
| Head and Neck | Central H&N Primary (n=9) | Lateral H&N Primary (n=18) | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Structure | Dose | Proton | IMRT | % Spared | P Value | Proton | IMRT | % Spared | P Value |
| Chiasm | Mean (Gy) | 26 | 28 | 7 | 0.35 | 15 | 24 | 38 | < 0.01 |
| V45 (%) | 35 | 37 | 5 | 0.11 | 5 | 14 | 64 | 0.34 | |
| Pituitary | Mean (Gy) | 32 | 35 | 9 | 0.02 | 25 | 33 | 24 | < 0.01 |
| V30 (%) | 64 | 67 | 4 | 0.17 | 49 | 63 | 22 | 0.03 | |
| Hypothalamus | Mean (Gy) | 9 | 15 | 40 | < 0.01 | 7 | 15 | 53 | < 0.01 |
| V16 (%) | 27 | 46 | 41 | 0.02 | 19 | 35 | 46 | 0.03 | |
| Brainstem | Mean (Gy) | 9 | 18 | 50 | < 0.01 | 8 | 18 | 56 | < 0.01 |
| V30 (%) | 8 | 21 | 62 | 0.07 | 9 | 22 | 59 | 0.02 | |
| Cerebellum | Mean (Gy) | 3 | 12 | 75 | < 0.01 | 5 | 15 | 67 | < 0.01 |
| V20 (%) | 1 | 18 | 94 | 0.05 | 7 | 26 | 73 | < 0.01 | |
| Maxilla | Mean (Gy) | 22 | 30 | 27 | < 0.01 | 15 | 30 | 50 | < 0.01 |
| V20 (%) | 48 | 71 | 32 | < 0.01 | 32 | 70 | 54 | < 0.01 | |
| V30 (%) | 38 | 55 | 31 | < 0.01 | 26 | 44 | 41 | < 0.01 | |
| Mandible | Mean (Gy) | 11 | 19 | 42 | < 0.01 | 12 | 24 | 50 | < 0.01 |
| V20 (%) | 25 | 47 | 47 | < 0.01 | 24 | 50 | 52 | < 0.01 | |
| V30 (%) | 17 | 28 | 39 | 0.08 | 20 | 33 | 39 | < 0.01 | |
| Thyroid | Mean (Gy) | 2 | 4 | 50 | 0.12 | 2 | 3 | 33 | 0.09 |
| V10 (%) | 6 | 11 | 45 | 0.22 | 5 | 8 | 38 | 0.17 | |
| Optic Nerves | Mean (Gy) | 30 | 30 | 0 | 0.60 | -- | -- | -- | -- |
| V50 (%) | 27 | 34 | 21 | 0.36 | -- | -- | -- | -- | |
| Optic NerveIpsi | Mean (Gy) | -- | -- | -- | -- | 25 | 31 | 19 | 0.01 |
| V50 (%) | -- | -- | -- | -- | 11 | 6 | −45 | 0.45 | |
| Optic NerveContra | Mean (Gy) | -- | -- | -- | -- | 9 | 21 | 57 | < 0.01 |
| Temporal Lobes | Mean (Gy) | 6 | 10 | 40 | < 0.01 | -- | -- | -- | -- |
| V20 (%) | 10 | 18 | 44 | 0.01 | -- | -- | -- | -- | |
| V30 (%) | 8 | 9 | 11 | 0.01 | -- | -- | -- | -- | |
| Temp LobeIpsi | Mean (Gy) | -- | -- | -- | -- | 12 | 21 | 43 | < 0.01 |
| V20 (%) | -- | -- | -- | -- | 23 | 44 | 48 | < 0.01 | |
| V30 (%) | -- | -- | -- | -- | 18 | 31 | 42 | < 0.01 | |
| Temp LobeContra | Mean (Gy) | -- | -- | -- | -- | 2 | 9 | 78 | < 0.01 |
| V20 (%) | -- | -- | -- | -- | 4 | 10 | 60 | 0.05 | |
| V30 (%) | -- | -- | -- | -- | 1 | 3 | 67 | 0.04 | |
| Lens | Mean (Gy) | 3 | 5 | 40 | 0.02 | -- | -- | -- | -- |
| V5 (%) | 20 | 48 | 58 | 0.01 | -- | -- | -- | -- | |
| LensIpsi | Mean (Gy) | -- | -- | -- | -- | 2 | 9 | 78 | 0.01 |
| V5 (%) | -- | -- | -- | -- | 16 | 63 | 75 | < 0.01 | |
| LensContra | Mean (Gy) | -- | -- | -- | -- | 0.2 | 6 | 97 | < 0.01 |
| V5 (%) | -- | -- | -- | -- | 0 | 46 | 100 | < 0.01 | |
| Retina | Mean (Gy) | 16 | 18 | 11 | 0.47 | -- | -- | -- | -- |
| V45 (%) | 8 | 6 | −25 | 0.88 | -- | -- | -- | -- | |
| RetinaIpsi | Mean (Gy) | -- | -- | -- | -- | 13 | 19 | 32 | 0.01 |
| V45 (%) | -- | -- | -- | -- | 8 | 5 | −38 | 0.12 | |
| RetinaContra | Mean (Gy) | -- | -- | -- | -- | 3 | 11 | 73 | < 0.01 |
| Cochlea | Mean (Gy) | 19 | 19 | 0 | 0.57 | -- | -- | -- | -- |
| V36 (%) | 17 | 4 | −76 | 0.18 | -- | -- | -- | -- | |
| CochleaIpsi | Mean (Gy) | -- | -- | -- | -- | 36 | 39 | 8 | 0.24 |
| V36 (%) | -- | -- | -- | -- | 62 | 63 | 2 | 0.83 | |
| CochleaContra | Mean (Gy) | -- | -- | -- | -- | 5 | 17 | 71 | < 0.01 |
| V20 (%) | -- | -- | -- | -- | 12 | 32 | 63 | 0.06 | |
| Lacrimal Gland | Mean (Gy) | 6 | 11 | 45 | < 0.01 | -- | -- | -- | -- |
| V20 (%) | 9 | 25 | 64 | 0.02 | -- | -- | -- | -- | |
| LacrimalIpsi | V30 (%) | 4 | 4 | 0 | 0.25 | -- | -- | -- | -- |
| Mean (Gy) | -- | -- | -- | -- | 9 | 15 | 40 | < 0.01 | |
| V20 (%) | -- | -- | -- | -- | 18 | 29 | 38 | 0.02 | |
| V30 (%) | -- | -- | -- | -- | 11 | 19 | 42 | 0.08 | |
| LacrimalContra | Mean (Gy) | -- | -- | -- | -- | 1 | 8 | 88 | < 0.01 |
| Parotid Gland | Mean (Gy) | 18 | 26 | 31 | 0.08 | -- | -- | -- | -- |
| V36 (%) | 22 | 21 | −5 | 0.33 | -- | -- | -- | -- | |
| ParotidIpsi | Mean (Gy) | -- | -- | -- | -- | 37 | 39 | 5 | 0.06 |
| V36 (%) | -- | -- | -- | -- | 66 | 64 | −3 | 0.66 | |
| ParotidContra | Mean (Gy) | -- | -- | -- | -- | 2 | 11 | 82 | < 0.01 |
| Skin | DMax (Gy) | 32 | 32 | 0 | 0.75 | 44 | 44 | 0 | 0.63 |
Abbreviations: ipsi, ipsilateral; contra, contralateral, temp; temporal.