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Tau aggregates induce an acute decrease of ISF tau levels in 3-month-old P301S tg mice. A, Tau aggregates containing the MTBR. MTBR is not recognized by tau antibodies (BT-2, Tau-5) used in ELISA. B, Relative e-tau levels after injection of vehicle (n = 3) or MTBR aggregates (n = 4) in P301S tg mice were measured by ELISA. *p < 0.05.
