Loss of Bmp4 and Msx1 expression coincides with the loss of odontogenic capability of dental mesenchyme in K14Cre;pNog mice. (A-L) In situ hybridization of Bmp4 (A,B,E,F,I,J) and Msx1 (C,D,G,H,K,L) in controls (WT) and in K14Cre;pNog tooth at E13.5 (A-D), E14.5 (E-H) and E15.5 (I-L). Scale bars: 50 µm. (M-P) Tooth formation in tissue recombinants of dental mesenchyme from K14Cre;pNog mice and wild-type dental epithelium at E12.5 (M), E13.5 (N) and E14.5 (O), but not in recombinants of E15.5 dental tissues (P) after 10-day kidney capsule culture. Scale bars: 100 µm.